abstract：OBJECTIVES:To audit services for prenatal diagnosis for haemoglobin disorders in the United Kingdom. DESIGN:Comparison of the annual number of cases recorded in a United Kingdom register of prenatal diagnoses for haemoglobin disorders, with the annual number of pregnancies at risk of these disorders, by ethnic group a...

journal_title：BMJ (Clinical research ed.)

authors： Modell B,Petrou M,Layton M,Varnavides L,Slater C,Ward RH,Rodeck C,Nicolaides K,Gibbons S,Fitches A,Old J

更新日期：1997-09-27 00:00:00

abstract：OBJECTIVE:To assess the effect of size at birth, maternal nutrition, and body mass index on blood pressure in late adolescence. DESIGN:Population based analysis of birth weight corrected for gestational age, mother's weight before pregnancy and weight gain in pregnancy, obtained from the Jerusalem perinatal study, and...

journal_title：BMJ (Clinical research ed.)

authors： Laor A,Stevenson DK,Shemer J,Gale R,Seidman DS

更新日期：1997-08-23 00:00:00

abstract：OBJECTIVE:To determine the relative contribution of decline in bone density to the increase in risk of hip fracture with age in men and women. DESIGN:Incidence data of hip fracture from the general population were combined with the bone density distribution in a sample from the same population and with a risk estimate...

journal_title：BMJ (Clinical research ed.)

authors： De Laet CE,van Hout BA,Burger H,Hofman A,Pols HA

更新日期：1997-07-26 00:00:00

abstract：OBJECTIVES:To determine the prevalence of drug and alcohol use among newly remanded prisoners, assess the effectiveness of prison reception screening, and examine the clinical management of substance misusers among remand prisoners. DESIGN:A consecutive case study of remand prisoners screened at reception for substanc...

journal_title：BMJ (Clinical research ed.)

authors： Mason D,Birmingham L,Grubin D

更新日期：1997-07-05 00:00:00

abstract：:The disease management approach to patient care seeks to coordinate resources across the healthcare delivery system. The growing interest in evidence based medicine and outcomes, and a commitment to integrated care across the primary, secondary, and community care sectors, all contribute to making disease management a...

journal_title：BMJ (Clinical research ed.)

authors： Hunter DJ,Fairfield G

更新日期：1997-07-05 00:00:00

abstract：OBJECTIVE:To evaluate risk of late life coronary heart disease associated with being overweight in late middle or old age and to assess whether weight change modifies this risk. DESIGN:Longitudinal study of subjects in the epidemiological follow up study of the national health and nutrition examination survey I. SETT...

journal_title：BMJ (Clinical research ed.)

authors： Harris TB,Launer LJ,Madans J,Feldman JJ

更新日期：1997-06-21 00:00:00

abstract：:Managed care has entered the lexicon of healthcare reform, but confusion and ignorance surround its meaning and purpose. It seeks to cut the costs of health care while maintaining its quality, but the evidence that it is able to achieve these aims is mixed. As well as raising awareness and understanding of the issues ...

journal_title：BMJ (Clinical research ed.)

authors： Fairfield G,Hunter DJ,Mechanic D,Rosleff F

更新日期：1997-06-21 00:00:00

abstract：OBJECTIVE:To study the comparative importance of environment and genes in the development of islet cell autoimmunity associated with insulin dependent diabetes mellitus. DESIGN:Population based study of diabetic twins. SETTING:Danish population. SUBJECTS:18 monozygotic and 36 dizygotic twin pairs with one or both pa...

journal_title：BMJ (Clinical research ed.)

authors： Petersen JS,Kyvik KO,Bingley PJ,Gale EA,Green A,Dyrberg T,Beck-Nielsen H

更新日期：1997-05-31 00:00:00

abstract：OBJECTIVES:To support already established epidemiological links between inmates of Glenochil prison positive for HIV infection by using molecular techniques and thus provide evidence of the extent of acquisition during a recent outbreak of the disease resulting from needle sharing. To identify possible sources of the o...

journal_title：BMJ (Clinical research ed.)

authors： Yirrell DL,Robertson P,Goldberg DJ,McMenamin J,Cameron S,Leigh Brown AJ

更新日期：1997-05-17 00:00:00

abstract：OBJECTIVE:To compare direct and indirect costs of day and inpatient treatment of acute psychiatric illness. DESIGN:Randomised controlled trial with outcome and costs assessed over 12 months after the date of admission. SETTING:Teaching hospital in an inner city area. SUBJECTS:179 patients with acute psychiatric illn...

journal_title：BMJ (Clinical research ed.)

authors： Creed F,Mbaya P,Lancashire S,Tomenson B,Williams B,Holme S

更新日期：1997-05-10 00:00:00

abstract：:The World Health Organization's (WHO) definition of health as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity" had the merit of widening concepts of health to include psychological and social aspects, but is of no practical use. In fact, this statement m...

journal_title：BMJ (Clinical research ed.)

authors： Saracci R

更新日期：1997-05-10 00:00:00

abstract：OBJECTIVE:To describe risk factors for infantile colic. DESIGN:Questionnaire administered by health visitors. SETTING:Sheffield. SUBJECTS:Mothers of 76,747 infants born between 1 August 1975 and 31 May 1988, interviewed when the infant was 1 month old. MAIN OUTCOME MEASURES:Reporting of infantile colic and its dura...

journal_title：BMJ (Clinical research ed.)

authors： Crowcroft NS,Strachan DP

更新日期：1997-05-03 00:00:00

abstract：OBJECTIVE:To determine whether peer review medical audit in a primary care setting changes clinical behaviour in relation to the management of hypertension. DESIGN:Review of medical records in general practices to identify hypertensive patients followed up by assessment of the pre-educational and post-educational mana...

journal_title：BMJ (Clinical research ed.)

authors： Mashru M,Lant A

更新日期：1997-03-29 00:00:00

abstract：OBJECTIVE:To describe the complete range of factors which doctors recognise as changing their clinical practice and provide a measure of how often education is involved in change. DESIGN:Interviews using the critical incident technique. SETTING:Primary and secondary care. SUBJECTS:Random sample of 50 general practit...

journal_title：BMJ (Clinical research ed.)

authors： Allery LA,Owen PA,Robling MR

更新日期：1997-03-22 00:00:00

abstract：:The meaning of the GP contract has changed since the last major upheaval in the mid-1960s. The government has always dealt with general practitioners as independent contractors, but the way in which it treated them in 1990 was entirely different from the way in which they were treated in 1966. In 1966, the profession'...

journal_title：BMJ (Clinical research ed.)

authors： Lewis J

更新日期：1997-03-22 00:00:00

abstract：OBJECTIVE:To evaluate the association between use of hormone replacement therapy and the risk of idiopathic venous thromboembolism. DESIGN:Population based case-control study. SETTING:Population enrolled in the General Practice Research Database, United Kingdom. SUBJECTS:A cohort of 347,253 women aged 50 to 79 witho...

journal_title：BMJ (Clinical research ed.)

authors： Pérez Gutthann S,García Rodríguez LA,Castellsague J,Duque Oliart A

更新日期：1997-03-15 00:00:00

abstract：:Lung cancer, the most prevalent cancer in the Western world, is mainly caused by smoking. Nevertheless, only 20% of smokers develop lung cancer and while prevention is important, environmental factors are expected to contribute to the predicted rise in the incidence of lung cancer in the next 25 years. Survival of lun...

journal_title：BMJ (Clinical research ed.)

authors： Sethi T

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To determine the relative importance of appropriate prescribing for asthma in explaining high rates of hospital admission for asthma among east London general practices. DESIGN:Poisson regression analysis describing relation of each general practice's admission rates for asthma with prescribing for asthma an...

journal_title：BMJ (Clinical research ed.)

authors： Griffiths C,Sturdy P,Naish J,Omar R,Dolan S,Feder G

更新日期：1997-02-15 00:00:00

abstract：:Currently, clinicians have to make decisions about how to manage pulmonary embolism on the basis of imperfect tests and assessment of odds. Management protocols that inevitably result in large numbers of patients being referred for angiography are unhelpful. Management decisions based on assessment of odds and investi...

journal_title：BMJ (Clinical research ed.)

authors： Fennerty T

更新日期：1997-02-08 00:00:00

abstract：OBJECTIVE:To evaluate the immunogenicity and reactogenicity of a new triple S recombinant hepatitis B vaccine in a cohort of healthy people in whom currently licensed hepatitis B vaccines had persistently not induced an immune response. DESIGN:Single centre, randomised, double blind, dose-response study. SETTING:Rese...

journal_title：BMJ (Clinical research ed.)

authors： Zuckerman JN,Sabin C,Craig FM,Williams A,Zuckerman AJ

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To investigate the contribution of neuroleptic drugs to cognitive decline in dementia. DESIGN:Two year prospective, longitudinal study consisting of interviews every four months, with necropsy follow up. SETTING:Community settings in Oxfordshire. SUBJECTS:71 subjects with dementia, initially living at home...

journal_title：BMJ (Clinical research ed.)

authors： McShane R,Keene J,Gedling K,Fairburn C,Jacoby R,Hope T

更新日期：1997-01-25 00:00:00

abstract：:Molecular techniques have revolutionised our knowledge of cell and tissue function in both health and disease. We already have new and powerful treatments based on an understanding of communication between cells by messenger molecules called cytokines. Furthermore, there is great therapeutic promise in defining molecu...

journal_title：BMJ (Clinical research ed.)

authors： Savill J

更新日期：1997-01-18 00:00:00

abstract：OBJECTIVE:To cost the relation between socioeconomic status and various measures of primary care workload and assess the adequacy of current "deprivation" payments in relation to actual costings for patients living in qualifying areas. DESIGN:Retrospective data on primary care were collected over a 4.5 year period fro...

journal_title：BMJ (Clinical research ed.)

authors： Worrall A,Rea JN,Ben-Shlomo Y

更新日期：1997-01-04 00:00:00

abstract：OBJECTIVES:To investigate the possible influence of attendance at cultural events, reading books or periodicals, making music or singing in a choir as determinants for survival. DESIGN:A simple random sample was drawn of 15,198 individuals aged 16-74 years. Of these, 85% (12,982) were interviewed by trained non-medica...

journal_title：BMJ (Clinical research ed.)

authors： Bygren LO,Konlaan BB,Johansson SE

更新日期：1996-12-21 00:00:00

abstract：OBJECTIVE:To investigate strength of associations between risk factors for cardiovascular disease and socioeconomic position during childhood and adulthood. DESIGN:Cross sectional analysis of status of cardiovascular risk factors and past and present social circumstances. SUBJECTS:5645 male participants in the west o...

journal_title：BMJ (Clinical research ed.)

authors： Blane D,Hart CL,Smith GD,Gillis CR,Hole DJ,Hawthorne VM

更新日期：1996-12-07 00:00:00

abstract：OBJECTIVES:To examine the association of plasma caffeine concentrations during pregnancy with fetal growth and to compare this with relations with reported caffeine intake. DESIGN:Prospective population based study. SETTING:District general hospital, inner London. SUBJECTS:Women booking for delivery between 1982 and...

journal_title：BMJ (Clinical research ed.)

authors： Cook DG,Peacock JL,Feyerabend C,Carey IM,Jarvis MJ,Anderson HR,Bland JM

更新日期：1996-11-30 00:00:00

abstract：OBJECTIVE:To assess whether causal criteria can be used to find out whether there is support in published research for maintaining that menopause causes depression. DESIGN:Ninety four articles from 30 years of research examining the relation of natural menopause to depression were traced by using Medline and systemati...

journal_title：BMJ (Clinical research ed.)

authors： Nicol-Smith L

更新日期：1996-11-16 00:00:00

abstract：:With the aim of promoting the informed choice of pregnant women, staff and pregnant women at two urban hospitals were offered leaflets summarising the best available evidence about the effectiveness of routine ultrasonography in early pregnancy. Ultrasonographers doubted the credibility of the evidence and were concer...

journal_title：BMJ (Clinical research ed.)

authors： Oliver S,Rajan L,Turner H,Oakley A,Entwistle V,Watt I,Sheldon TA,Rosser J

更新日期：1996-11-16 00:00:00

abstract：OBJECTIVE:To assess the role of rhinoviruses in elderly people living in the community. DESIGN:Prospective community based surveillance of elderly people, without intervention. Subjects were telephoned weekly to identify symptomatic upper respiratory tract infections. Symptoms and impact of illnesses were monitored, a...

journal_title：BMJ (Clinical research ed.)

authors： Nicholson KG,Kent J,Hammersley V,Cancio E

更新日期：1996-11-02 00:00:00

abstract：OBJECTIVE:To identify and explore parents' concerns when young children become acutely ill. DESIGN:Qualitative study making use of semi-structured one to one and group interviews with parents of preschool children. SETTING:Disadvantaged inner city community. SUBJECTS:95 parents of preschool children. RESULTS:Fever,...

journal_title：BMJ (Clinical research ed.)

authors： Kai J

更新日期：1996-10-19 00:00:00

abstract：OBJECTIVES:Analysis of incidence and characteristics of congenital abdominal wall defects, with special reference to the differences between the incidence of gastroschisis and exomphalos (omphalocele). DESIGN:Retrospective analysis using data from the Office of Population Censuses and Surveys (recoded to differentiate...

journal_title：BMJ (Clinical research ed.)

authors： Tan KH,Kilby MD,Whittle MJ,Beattie BR,Booth IW,Botting BJ

更新日期：1996-10-12 00:00:00

abstract：OBJECTIVE:To examine differences in morbidity and mortality due to non-insulin dependent diabetes in African Caribbeans and Europeans. DESIGN:Cohort study of patients with non-insulin dependent diabetes drawn from diabetes clinics in London. Baseline investigations were performed in 1975-7; follow up continued until 1...

journal_title：BMJ (Clinical research ed.)

authors： Chaturvedi N,Jarrett J,Morrish N,Keen H,Fuller JH

更新日期：1996-10-05 00:00:00

abstract：:The aim of community care is to enable people with various types of disability to live in their own homes, rather than in institutions. This involves the provision of support and services at home by various agencies. After a critical report in 1986 identified problems with coordination and flexibility of community car...

journal_title：BMJ (Clinical research ed.)

authors： Renwick D

更新日期：1996-10-05 00:00:00

abstract：OBJECTIVE:To examine whether the decline in child injury death rates between 1981 and 1991 varied by social class. DESIGN:Comparison of class specific child injury death rates for 1979, 1980, 1982, and 1983, with those for the four years 1989-92. SETTING:England and Wales. SUBJECTS:Children aged 0-15 years. MAIN OU...

journal_title：BMJ (Clinical research ed.)

authors： Roberts I,Power C

更新日期：1996-09-28 00:00:00

abstract：OBJECTIVE:To determine the contribution of inheritance to the incidence of squamous cell carcinoma of the head and neck. DESIGN:Historical cohort study. First degree relatives of cases with squamous cell carcinoma of the head and neck made up the exposed cohort and first degree relatives of spouses of cases made up th...

journal_title：BMJ (Clinical research ed.)

authors： Foulkes WD,Brunet JS,Sieh W,Black MJ,Shenouda G,Narod SA

更新日期：1996-09-21 00:00:00

abstract：OBJECTIVE:To assess the effect on time to diagnosis of recurrence and on quality of life of transferring primary responsibility for follow up of women with breast cancer in remission from hospital to general practice. DESIGN:Randomised controlled trial with 18 month follow up in which women received routine follow up ...

journal_title：BMJ (Clinical research ed.)

authors： Grunfeld E,Mant D,Yudkin P,Adewuyi-Dalton R,Cole D,Stewart J,Fitzpatrick R,Vessey M

更新日期：1996-09-14 00:00:00

abstract：OBJECTIVE:To investigate the variation in prescribing among general practices by examining the contribution to this variation of fundholding, training status, partnership status, and the level of deprivation in the practice population and to investigate the extent to which fundholding has been responsible for any chang...

journal_title：BMJ (Clinical research ed.)

authors： Wilson RP,Hatcher J,Barton S,Walley T

更新日期：1996-09-07 00:00:00

abstract：OBJECTIVE:To investigate explanations for social inequalities in health with respect to health related social mobility and cumulative socioeconomic circumstances over the first three decades of life. DESIGN:Longitudinal follow up. SETTING:Great Britain. SUBJECTS:Data from the 1958 birth cohort study (all children bo...

journal_title：BMJ (Clinical research ed.)

authors： Power C,Matthews S,Manor O

更新日期：1996-08-24 00:00:00

abstract：:The instrument through which a commissioner purchases health services from a provider is, as in other walks of life, a contract, so considerable importance has been attached by the NHS Executive to the contracting mechanism. A contract should in theory influence the quality of the service provided, but they are in man...

journal_title：BMJ (Clinical research ed.)

authors： Hopkins A,Solomon JK

更新日期：1996-08-24 00:00:00

abstract：OBJECTIVE:To estimate the usefulness of serum concentrations of the complex of trypsin 2 and alpha 1 antitrypsin in diagnosing and assessing the severity of acute pancreatitis in comparison with serum C reactive protein, amylase, and trypsinogen 2 concentrations (reference markers). DESIGN:Markers were measured in con...

journal_title：BMJ (Clinical research ed.)

authors： Hedström J,Sainio V,Kemppainen E,Haapiainen R,Kivilaakso E,Schröder T,Leinonen J,Stenman UH

更新日期：1996-08-10 00:00:00